Breast Cancer

Improve Breast Cancer Treatment Results with Hyperthermia

Breast cancer is the most common cancer in women worldwide according to the World Cancer Research Fund International. With nearly 1.7 million new cases diagnosed in 2012 (second most common cancer overall). This represents about 12% of all new cancer cases and 25% of all cancers in women.

Clinical results like the one below reveal that both Chemotherapy and Radiation treatment are more effective when combined with Hyperthermia. Hyperthermia warms the tumor to temperatures in the "fever range" which makes the cancer cells more sensitive to treatment. Normal healthy cells recover while cancer cells die.

Clinical Evidence

Tumor Entity:

Results of five randomized controlled trials on radiation with or without hyperthermia in advanced or recurrent breast cancer were combined in one analysis.

Treatment Modality:

Radiotherapy, dose and scheme depending on previous irradiation or not, and varying per trial. Superficial hyperthermia was applied once or twice weekly.

Clinical Results:

The combination of results in total 306 patients showed a significant improvement in complete response rate in the group treated with radiotherapy and hyperthermia: 59% vs 41%. This initial improvement in local tumor control was maintained during follow-up. In one of the trials (ESHO), all patients were treated after previous irradiation and reirradiated with 8 fractions of 4 Gy, two fractions per week. The difference in local tumor control between the two treatment arms was significant and remarkably high in this subgroup: CR rate was 39% without hyperthermia, and 79% with hyperthermia, with similar differences in local tumor control during follow-up. Not all trials cited used the BSD-500 specifically.

Evidence Level I Randomized Clinical Trial Results on 306 Patients (Vernon et al.):

  • Complete Remission Rate without Hyperthermia: 41 %
  • Complete Remission Rate with Hyperthermia: 59 %

breast ht graph

Subgroup after previous irradiation and reirradiated (ESHO):

  • Complete Remission Rate without Hyperthermia: 39 %
  • Complete Remission Rate with Hyperthermia: 79 %

 breast ht 2 graph


The combination of Radiotherapy and Hyperthermia is the treatment of choice for Breast Cancer (Level I Evidence) recommended by

Hyperthermia and Radiotherapy:

When hyperthermia is combined with radiotherapy, general treatment guidelines of the ESHO European Society of Hyperthermic Oncology recommend:

  • Target volume for hyperthermia: When the radiotherapy total dose is considered to be sufficient for a high probability of local control for microscopic disease, the target volume for hyperthermia is the gross tumor volume. When the radiotherapy total dose is lower, the target volume for hyperthermia is the clinical target volume.
  • Sequence of treatment modalities: Hyperthermia is given after the radiotherapy fraction, once or twice weekly with a time interval between two hyperthermia treatments of minimum 72 hours. The time interval between radiotherapy and hyperthermia may vary from 30 minutes to five hours.
  • Duration of hyperthermia treatment: Superficial hyperthermia total 60 minutes, deep hyperthermia maximally 90 minutes (including up to 30 minutes heating-up time) at temperatures of 40 to 44 °C in the whole target volume.


Breast Case Study

anal barchart
Complete Remission
  • without Hyperthermia: 39%
  • with Hyperthermia:  79%
  • Level 1 Radomized Clinical Evidence

Become a Cancer Fighter

breast ribbonHyperthermia is minimally invasive, and can increases the effectiveness of some breast cancer treatments.

The American Cancer Society’s estimates for breast cancer in the United States for 2015 are:

  • About 231,840 new cases of invasive breast cancer will be diagnosed in women
  • About 40,290 women will die from breast cancer

How can you save a life?

Spread the word about Hyperthermia